Postponed: BORAM XVII MEETING at Virginia Tech: June 1-5, 2021
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We are a chemistry lab who apply organic synthesis in medicinal chemistry and chemical biology. Central to our work is synthetic methods development and discovery of molecules that improve human health.
Synthetic Methods
Methods that install boron and silicon atoms into carbon-carbon bonds
RNA Targeting
Branched peptides as molecular scaffold to target HIV-1 RNA structures
Drug Discovery
Inhibitors of sphingosine kinases and S1P transporters for the potential treatment of multiple sclerosis, metastatic cancers and kidney fibrosis.
Mitochondrial uncouplers against fatty liver disease, obesity, and aging.
Recent News
- 6.15.2020 Congratulations to @santoslabVT PhD #17: Dr. Christopher Sibley. Amazing work and excellent dissertation defense. Chris is a double Hokie! #Hokies
- 6.09.2020 Russell Snead and Jan Nekvinda’s work on the borylation of allenes in water is published in the New J. Chem. Well done!
- 5.27.2020 Chris Garcia and Joe Salamoun detail their structure-activity profiling of mitochondrial uncouplers. Their lead compound is efficacious against NASH–published in J. Med. Chem. Congrats!!!
- 5.15.2020 Our collaborative work with the Hoehn Labs is published in Nature Communications. BAM15 induced fat loss without changes in food intake or lean body mass.
- 5.14.2020 Russell and Jan published their work on phosphinoboration of internal alkynes. Congrats!